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Figure 1 Blood pressures at baseline and after three weeks of angiotensin II (AngII) infusion in wild-type (WT) and osteopontin-null (OPN^–/–) mice. Basal blood pressure (BP) is lower in OPN^–/– mice versus WT mice (^xp < 0.01). Systolic blood pressure (SBP) of each group increased significantly versus untreated mice (*p < 0.05 WT; p < 0.05 OPN^–/–) when infused with AngII at 2.5 µg/kg/min. Infusion of AngII at 3 µg/kg/min increased BP in OPN^–/– mice versus OPN^–/– basal values, and to a higher absolute systolic pressure versus either WT or OPN^–/– mice infused at the lower 2.5 µg/kg/min dosing. 2.5 AngII = AngII at 2.5 µg/kg/min; 3 AngII = AngII at 3 µg/kg/min. Mean change in SBP of WT and OPN^–/– mice from sham-infused and after three weeks' treatment with AngII at 2.5 µg/kg/min was identical. The SBP in OPN^–/– mice treated with AngII at 3 µg/kg/min was significantly higher than in OPN^–/– mice or WT mice treated with AngII at 2.5 µg/kg/min (+p < 0.001 vs. 2.5 µg/kg/min AngII-infused WT or OPN^–/– mice).

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