Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 3 Bar graphs summarizing the mean data of myocardial [18F]-2-deoxy-2-fluoro-D-glucose (FDG) uptake in GLUT4-null and wild-type mice (expressed as standard uptake values [SUVs], y-axis), using quantitative analysis of (A) in vivo positron emission tomography imaging and (B) in vitro gamma-counter tissue biodistribution studies. The positron emission tomography study was performed under the following conditions: baseline, simultaneous injection of insulin and FDG, and 60-min delay. The gamma-counter biodistribution study provides a more detailed time course of insulin-stimulated FDG uptake as 30-min and 120-min delay times points were also investigated. *p < 0.05 for comparisons with baseline values.  p < 0.05 for comparisons between GLUT4-null and wild-type animals in each experimental condition. GLUT = glucose transporter.
|
