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Figure 4 Representative current traces of Ito in rabbits of the control (a) and beta groups (b). The Ito elicited by the voltage-clamp protocol in the inset was normalized to the cell capacitance. The measured maximum outward current was averaged and plotted against the test potential (c). The Ito density obtained from the beta group rabbits was significantly smaller than that from control group rabbits. The Ito density, elicited by the test pulse to +70 mV at the various pulse-to-pulse interval, is shown in (d). See text for details. (Data were obtained from isolated left ventricular myocytes from the M-cell region). C = control.
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