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Figure 2 Hemodynamic measurements in the non-ischemic isolated rat heart perfused with minocycline (MNC) (10–5 to 10–7 M) for 1 h. Changes in left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) are shown in A and B, respectively. Results are expressed as mean ± SD. Mechanical function of the isolated rat heart during ischemia/reperfusion (I/R), with and without pretreatment with minocycline (C to E). CTRL = control; Solid triangles = LVSP; open squares = LVEDP.





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