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Figure 2 Typical examples of grading of the histologic findings (hematoxylin-eosin staining x400). (a) No fibrosis, no muscle bundle fragmentation, and no myocyte degeneration (histopathologic contractility failure index = 0). (b) Severe fibrosis but no degenerative change (scores: fibrosis = 3; fragmentation = 3; degeneration = 0). (c) Severe muscle bundle fragmentation but mild degeneration (scores: fibrosis = 2; fragmentation = 3; degeneration = 1). (d) Severe degeneration but no fibrosis (scores: fibrosis = 0; fragmentation = 0; degeneration = 3).
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