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Figure 3 Hemodynamic and gas-exchange response to inhaled nitric oxide (NO), infused PGI2, and oral sildenafil in patients with lung fibrosis and pulmonary hypertension. Deviations from preintervention baseline are displayed for inhaled NO, infused prostacyclin (PGI iv), and oral sildenafil (Sil oral). CO = cardiac output; mPAP = mean pulmonary arterial pressure; mSAP = mean systemic arterial pressure; PaO
2 = partial pressure of arterial oxygen (changes in mm Hg); PVRI = pulmonary vascular resistance index; PVR/SVR ratio = ratio of pulmonary to systemic vascular resistance (adapted from Ghofrani et al., Lancet 2002;360:895–900).
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