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Figure 2 Comparison of pulmonary vasodilative potency of oral sildenafil, inhaled nitric oxide (NO), and inhaled iloprost. Comparative vasodilator testing was performed in 30 patients with precapillary pulmonary hypertension. In each group, the effect of inhaled NO on pulmonary vascular resistance (PVR) was compared with that of sildenafil, inhaled iloprost, or a combination of both. In the upper left figure, inhaled NO and iloprost were compared with a low dose of sildenafil (12.5 mg), while in the upper right figure a combination of sildenafil and iloprost was tested. The lower left figure summarizes the effects of 50 mg sildenafil compared to NO and iloprost, and the lower right figure shows the data of a combination of high-dose sildenafil with iloprost (adapted from Ghofrani et al., Ann Intern Med 2002;136:515–22).
