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Figure 1 Hemodynamic effects of bosentan versus placebo at 12 weeks. Significant improvements in cardiac index (CI), pulmonary vascular resistance (PVR), and mean pulmonary arterial pressure (mPAP) were all noted. The placebo group worsened over the 12-week period. Adapted from Channick et al. (27)—original work. Control group is shown in blue; bosentan group is shown in green.  Significant improvement versus baseline; *Significant decline versus baseline.
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