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Figure 3 Serotonin receptors and transporter in pulmonary artery smooth muscle cells. The 5-hydroxytryptamine transporter (5-HTT) expression, activity, or both in pulmonary artery smooth muscle cells contribute to pulmonary vascular remodeling. The 5-HT1B mediates contraction in human pulmonary artery smooth muscle cells. A role for other 5-hydroxytryptamine (5-HT) receptors such as 5-HT2A and 5-HT2B has also been suggested.
