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Figure 3 Effects of L-NAME (50 mg/kg), MEG sodium succinate (10 mg/kg), and FeTPPS (30 mg/kg) on endotoxin-induced heart I-kappa-B degradation and plasma tumor necrosis factor (TNF)-alpha levels. See Methods section for treatment group design. (A) Degradation of I-kappa-B (n = 5 in each group). Semiquantitative analysis was performed on the basis of relative I-kappa-B/G3PDH density. (B) Plasma TNF-alpha levels (n = 6 in each group). Results are expressed as mean ± SEM. *p < 0.01 compared with control; #p < 0.01 compared with endotoxin-treated rats. Abbreviations as in Figure 1.
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