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Figure 1 Electron microscopic images of human hibernating myocardium (HHM). (A) Degenerative changes with numerous autophagic vacuoles (AV) and a lack of nucleus, indicating autophagic cell death. (B) Widening of the interstitial space that contains fibroblasts (F), macrophages (small arrows), and cellular debris (CB). Note the lack of contractile material in one myocyte (arrow). (C) Apoptotic nuclear disassembly in a myocyte (thick arrows). Note the formation of an apoptotic body (thin arrows). All bars = 5 µm.