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Figure 3 Transplantation of vascular endothelial growth factor (VEGF)-165 expressing skeletal myoblasts (SKMB) significantly increases LV function. Eight weeks after myocardial infarction, the peri-infarct zone was injected with either saline (n = 7), 1 x 107 pfu of adenoviral VEGF-165 (AdVEGF-165) (n = 4), or 1 million SKMB transfected with AdLuciferase (n = 7) or AdVEGF-165 (n = 6) in five equally divided injections. Left ventricular function was quantified four weeks later by echocardiogram. Left ventricular function is presented as shortening fraction (%) relative to saline control. Data represent mean ± SEM. *p < 0.03 compared with saline control. &p < 0.05 compared with SKMB.
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