Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 3 (A) Major QTc interval prolongation observed in a patient who had syncope only one month after the beginning of HQ. The SCN5A mutation was not found in this patient. Measurement of the QT interval includes the inverted T wave observed after the downsloping ST-segment elevation in lead V2. (B) Monomorphic runs of VT were recorded in the emergency room, but in only one lead. No recurrence of syncope was observed after withdrawal of HQ during a follow-up of one year. Syncope may be attributed to a drug inefficacy or to a proarrhythmic effect of HQ. The argument for drug failure is the absence of typical pause-dependent torsade de pointes and of a long coupling interval. The argument for a proarrhythmic event is major QTc interval prolongation. Abbreviations as in Figure 1.
|
