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Figure 2 Beta-adrenergic receptor (AR) number (Bmax) and beta-AR/Gs coupling. (A) The beta-AR number was assessed by a radioligand binding study. The beta-AR number was not significantly different among the three groups. (B) A characteristic reduction in high-affinity binding, denoting uncoupling of beta-ARs, was noted in myocardial samples from noninfarcted regions of untreated myocardial infarction (MI) animals (MI/control [C]) compared with shams. Treatment of MI animals with candesartan (MI/angiotensin II type 1 receptor blocker [ARB]) increased the proportion of receptors exhibiting high-affinity agonist binding. *p < 0.001 MI/C vs. sham;  p < 0.01 MI/ARB vs. MI/C; n = 6 in each group.
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