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Figure 2 Effects of androgen exposure on macrophage lipoprotein metabolism. (A) Androgen exposure increased the rate of lysosomal degradation of acetylated low-density lipoprotein (AcLDL) by male-donor monocyte-derived macrophages—a finding consistent with increased lysosomal acid lipase activity (p = 0.001 for dihydrotestosterone [DHT]-treated vs. control cells, at 20 h). (B) Androgen exposure had no effect on cell surface binding of 125I-AcLDL (p > 0.1 for androgen vs. control macrophages).
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