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Figure 1 Effects of therapy on two-year mortality in landmark trials of heart failure of varying symptomatic severity. ßB = beta-blocker; AA = aldosterone antagonist; ACEi = angiotensin-converting enzyme inhibitor; NYHA = New York Heart Association; Prev. = Prevention; Treat. = Treatment. CIBIS-II = Cardiac Insufficiency Bisoprolol Study-part II; CONSENSUS = Cooperative North Scandinavian Enalapril Survival Study; COPERNICUS = Carvedilol Prospective Randomised Cumulative Survival trial; EPHESUS = Eplerenone's Neurohormonal Efficacy and Survival Study; MERIT = Metoprolol CR/XL Randomized Intervention Trial in Heart Failure; RALES = Randomized Aldactone Evaluation Study; SOLVD = Studies Of Left Ventricular Dysfunction.
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