JACC
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J Am Coll Cardiol, 2003; 42:1140, doi:10.1016/S0735-1097(03)00889-1
© 2003 by the American College of Cardiology Foundation
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LETTER TO THE EDITOR

The T-786C endothelial nitric oxide synthase genotype and coronary artery disease

Alberto Batalla, MD, FESC, Julián R. Reguero, MD, FESC and Eliecer Coto, PhD

Department of Cardiology, Cabuenes Hospital, Cabrales 30-5°, 33201 Gijón (Asturias), Spain

abatalla{at}telecable.es

We read with interest the article in JACC by Rossi et al. (1). These investigators found that the C allele at the T-786C endothelial nitric oxide synthase (ecNOS) polymorphism is associated with a higher risk of coronary artery disease (CAD) in Caucasians, especially in subjects older than 60 years of age. In their report, the researchers affirm that there were no data supporting the relevance of the T-786C polymorphism in non-Japanese populations. However, a previously published study by our group (2) concluded that the NOS3-CC genotype would have a significantly increased risk of suffering an early episode of CAD in Spanish subjects. The study was based on 170 Spanish male patients (average age 42 ± 6 years) who had suffered an episode of CAD and had at least one angiographically confirmed diseased vessel, and on 300 controls younger than 60 years of age and without cardiovascular disease. According to our results, the -786ecNOS-CC genotype confers an increased risk of suffering an early episode of CAD, but additional studies on other populations are required to confirm these results.


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  1. Rossi GP, Cesari M, Zanchetta M, et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol. 2003;41:930–937[Abstract/Free Full Text]
  2. Alvarez R, Gonzalez P, Batalla A, et al. Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease. Nitric Oxide. 2001;5:343–348[CrossRef][Medline]




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