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Figure 5 Loss of ventricular pre-excitation in a mutant mouse. (Top panel) Electrocardiographic leads I, II (LI and LII), and aVF displayed from a TGN488I mouse. An electrocardiogram (ECG) pattern of pre-excitation is evident at postnatal week 2. At week 4, the phenotype was lost, but intermittent pre-excitation returned in week 5. By week 7, the phenotype was completely lost, with a normal ECG. (Bottom panel) Electrocardiographic leads are displayed, along with the HBE (EG). At week 10, adenosine infusion (arrow) during atrial burst pacing at 150 ms results in AV block with a slow ventricular response. A = atrial electrogram; V = ventricular electrogram.
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