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Figure 1 Cellular basis for the J-wave. (A) A prominent J-wave in lead II was recorded from a healthy, young Asian male. (B) Simultaneous recording of transmembrane action potentials (APs) from epicardial (Epi) and endocardial (Endo) regions and a transmural electrocardiogram (ECG) in an arterially perfused canine ventricular wedge preparation. An Ito-mediated AP notch in the epicardium, but not endocardium, was associated with a J-wave. A premature stimulus (S1 – S2 = 300 ms) caused a parallel decrease in the amplitude of the epicardial AP notch and J-wave. Modified from Yan and Antzelevitch (4), with permission.
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