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Figure 4 Effects of dehydroepiandrosterone (DHEA) exposure on macrophage gene expression. (A) Gene expression examined by reverse-transcription polymerase chain reaction shows that DHEA at physiologic concentrations upregulates the lipoprotein-processing genes acyl coenzyme A:cholesterol acyltransferase I (ACAT) and lysosomal acid lipase (LAL). (B) In contrast, DHEA exposure had no significant effect on expression of the scavenger receptors A1 and A2. *p < 0.05 versus control values for ACAT and LAL (vs. p > 0.2 for scavenger receptors A1 and 2). Open columns = control; shaded columns = DHEA at 42 nmol/l.
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