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Figure 4 (A) Skin blood flow during reactive hyperemia before and after cyclooxygenase inhibition with aspirin (percent change from baseline). Hyperemic skin blood flow is markedly reduced after oral administration of aspirin (*p = 0.025). (B) Skin blood flow during reactive hyperemia after intracutaneous administration of L-NAME, an inhibitor of nitric oxide synthase, and control (D-NAME), respectively (percent change from baseline). There is no significant difference in hyperemic skin blood flow.
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