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Figure 2 Distribution of patients (n = 14) in New York Heart Association (NYHA) functional classes. The numbers of patients classified in class II (open bars), III (bars with diagonal lines), or IV (solid bars) are given for the initial pre-intervention baseline, for three months of inhaled iloprost therapy (Ilo 3 months), for a mean interval of 18 ± 4 months when clinical deterioration was noted (Pre-Sil), and for 3, 6, and 9–12 months of adjunct sildenafil therapy while leaving the iloprost regimen unchanged (Sil-Ilo). Note that one patient died between three and six months and one died at eight months of adjunct sildenafil therapy (n = 13 penultimate and n = 12 ultimate column).
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