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Figure 1 Time course of 6-min walk distance in response to iloprost and sildenafil treatment. Mean and SEM are given for the 6-min walk distance. Data were obtained at baseline, after three months of inhaled iloprost therapy (Ilo 3 months), after a mean interval of 18 ± 4 months upon clinical deterioration (Pre-Sil), and after 3, 6, and 9 to 12 months of adjunct sildenafil therapy while leaving the iloprost regimen unchanged (Sil-Ilo). Plus signs with vertical bars on either side demonstrate significant differences in walk distance (assessed by Wilcoxon test, two-sided p values given) for the impact of adjunct sildenafil treatment.
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