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Figure 1 Differences in the action potential (AP) shape and duration in nontransgenic (Ntg) and transgenic (Tg) myocytes. Representative APs were recorded in single ventricular myocytes isolated from Ntg (2- and 8-month-old) and Tg mice (2-, 4-, 8-, and 9- to 12-month-old) (A). Effect of 4-aminopyridine (4-AP) on AP duration (B and C). Examples of AP recordings from mouse cardiomyocytes derived from eight-month-old Ntg (B) and Tg (C) mice before and after application of 250 µM 4-AP and washout.
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