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Figure 5 Impact of the randomized defibrillator trials on arrhythmic death. For each randomized trial, the number of arrhythmic deaths (n) and the number assigned (N) are shown. All studies showed consistent benefit in reducing arrhythmic death with the implantable cardioverter defibrillator (ICD), and there was no statistical heterogeneity between studies (p = 0.18). Over all studies reporting arrhythmic deaths, the defibrillator reduced the risk of arrhythmic death significantly (pooled relative risk 0.43; 95% CI 0.35 to 0.54). The ICD effect was a highly significant reduction in risk of arrhythmic death (p < 0.00001). The horizontal tips of the black diamond represent the 95% CI, and the midpoint of the diamond represents the point estimate of the RR. CABG Patch = Coronary Artery Bypass Graft Patch Trial; MADIT = Multicenter Automatic Defibrillator Implantation Trial; MUSTT = Multicenter Unsustained Tachycardia Trial. Other abbreviations as in Figure 4.
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