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Figure 1 Gene expression of four chemokines (A), four CC chemokine receptors (CCR) (B), and three CXC chemokine receptors (CXCR) (C) in healthy controls (CTR; n = 15 in A and B and n = 7 in C) and coronary artery disease (CAD) patients (CAD; n = 30) before statin therapy. Horizontal lines indicate median values. (A and B) Gene expression is assessed by ribonuclease protection assay, normalized to the house-keeping genes glyceraldehyde-3-phosphate-dehydrogenase (GAPDH), and data are presented as percentage of GAPDH expression. (C) Gene expression is assessed by quantitative reverse transcription-polymerase chain reaction and normalized to beta-actin expression. IL = interleukin; MIP = macrophage inflammatory protein; mRNA = messenger ribonucleic acid; RANTES = regulated upon activation, normally T cell expressed and secreted.
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