Table 2 Patient Data Before Left Ventricular Assist Device Support
| Pt. No. |
Clinical Description |
Pathologic Description |
Diagnosis* |
Age (yrs) |
Gender |
LVAD Duration (days) |
LVEF |
Patient History |
Medications |
|
| 1 |
Nonischemic IDC, CHF, and TdeP (Mod. enl.) |
IDC, very mild CAD, mild fibrosis (nonischemic distribution) |
5 |
61 |
M |
47 |
15% |
Hypercholesterolemia, lipidemia, gout |
Aspirin, Ativan, Coumadin, Lanoxin, Lasix, Toprol, Vasotec, Zocor, Zyrtec |
| 2 |
Nonischemic IDC, CHF (HB) (Sev. enl.) |
IDC, no CAD, mild fibrosis immediately surrounding LVAD tube |
5 |
52 |
M |
66 |
10% |
VT, HB, pacemaker, hyperthyroidism, PPH, acute renal failure |
Albuterol, amiodorone, aspirin, Carvedilol, digoxin, folate, KCl, Lasix, lisinopril, thiamine, Trazodone, Zaroxolyn |
| 3 |
Nonischemic IDC(Mod. enl.) |
IDC, no CAD, mild fibrosis, (nonischemic distribution) |
3 |
64 |
M |
64 |
15% |
Diabetes, edema, cough/sputum |
Coumadin, digoxin, insulin, KCl, Lasix, Restoril, spironolactone, Zaroxolyn |
| 4 |
Ischemic CM, CHF, post-CABG(Mild. enl.) |
Ischemic, CAD, bypass grafts, mild biventricular dilation |
7 |
45 |
M |
76 |
10% |
Diabetes, hypertension hyperlipidemia, renal insufficiency |
Aspirin, captopril, digoxin, insulin, Lasix, Zaroxolyn |
| 5 |
Ischemic CM, hypertensive ICM (Mild. enl.) |
Ischemic, CAD, atherosclerosis, fibrosis, mild biventricular dilation |
6 |
53 |
M |
53 |
15% |
Hypertension, AF, renal insufficiency |
Atorvastatin, digoxin, furosemide, KCl, losartan, spironolactone, warfarin, Zaroxolyn |
| 6 |
Ischemic CM, CAD, MI x4, CHF (Mild. enl.) |
Ischemic, CAD, bypass grafts, stents, multiple infarcts |
5 |
53 |
M |
34 |
10% |
Diabetes, bronchitis, COPD, hypertension, hyperlipidemia |
Accupril, aspirin, Benadryl, Colace, Combivent, digoxin, Lasix, metformin, Zantac |
|
|
|
Mean 5.2 ± 0.2 |
Mean 54.6 ± 1.0 |
|
Mean 56.6 ± 2.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
AF = atrial fibrillation; CABG = coronary artery bypass grafting; CAD = coronary artery disease; CHF = congestive heart failure; CM = cardiomyopathy; COPD = chronic obstructive pulmonary disorder; HB = heart block; ICM = hypertensive ischemic cardiomyopathy; IDC = idiopathic dilated cardiomyopathy; LVEF = left ventricular ejection fraction; MI = myocardial infarction; Mod. enl. or Sev. enl. = moderately or severely dilated left ventricular chamber; PPH = primary pulmonary hypertension; Pt. = patient; TdeP = torsades de pointes; VT = ventricular tachycardia.
* Years since initial diagnosis of heart failure.
Medications taken prior to LVAD placement. Clinical data from patients were obtained following initial gene expression data analysis based on segregation of patients before LVAD.
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