Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 4 Heart failure etiology-specific regulation of gene expression. (A) Raw Affymetrix average difference hybridization intensity values for ß-myosin heavy chain (MHC) and skeletal (SK)  -actin, demonstrating the divergent regulation of gene expression following LVAD support in different heart failure etiologies. (B) Signal to glyceraldehyde-6-phosphate dehydrogenase ratio of Northern blot data for ß-MHC and SK -actin, demonstrating concordance of trends in data seen by the Affymetrix GeneChip. Isch = ischemic patients; NI = nonischemic patients. Changes in gene expression values for these genes found by both microarray (A) and Northern Blot (B) p < 0.05 in NI patients and not significant in Isch patients, determined by paired t test.
|
