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Figure 2 Structure of lamin A/C gene (LMNA) and of the lamin A/C protein. LMNA encodes lamin A (664 amino acids) and lamin C (572 amino acids) by alternative splicing in exon 10. The region common to both lamins includes the globular head, the  -helical domain (coils 1a, 1b, and 2, separated by linkers depicted as diagonal stripes), and part of the tail (566 amino acids). The mutations identified in patients with DCM, the corresponding nucleotide, and their position on the protein are indicated (star = splice site mutation).
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