Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 1 The coagulation cascade. Interaction of the intrinsic pathway (initiated by the activation of Factor XI) and the extrinsic pathway (activated by vascular or tissue injury) results in a cascade of reactions that generate thrombin (Factor IIa). Thrombin is produced from prothrombin Factor II by the action of activated Factor X (Xa). Thrombin then acts on fibrinogen to generate fibrin, which undergoes crosslinking, resulting in a thrombin–fibrin clot.
|
