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Figure 4 The bar graph shows total birefringence (left bars of each group) and the ratio of red-orange to greenish-yellow fibers (right bars of each group) of Sirius red–stained sections of the LV of eight-week-old TGRen2, assessed with polarization microscopy. Total birefringence is expressed as percent of the total area pertaining to the sum of red-orange and greenish-yellow fibers, which roughly correspond to collagen type I and III, respectively. Total birefringence and the ratio of red-orange to greenish-yellow fibers were lower in bosentan-treated TGRen2 compared with placebo. The TGRen2 receiving irbesartan + BMS-182874 showed a significantly higher total birefringence compared with both bosentan- and irbesartan-treated TGRen2.
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