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Figure 3 Left ventricular collagen density, expressed as percent of the total area pertaining to fibrillar collagen (as visualized by the Sirius red staining) and measured by videodensitometry, was significantly decreased in bosentan- and irbesartan-treated eight-week-old TGRen2 compared with both age- and gender-matched placebo-treated TGRen2 and with BMS-182874 or BMS-182874 + irbesartan. The BMS-182874, either alone or combined with irbesartan, did not reduce collagen density compared with placebo.
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