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Figure 5 Evolution with aging of conduction parameters in affected (filled symbols) and unaffected subjects (open symbols). (A) Averaged and filtered P-wave duration. (B) PR duration. (C) QRS duration. In A and B, data were fitted with a linear regression analysis. In C, assessment of the residuals showed that the linear model was poorly adapted to fit the relation between QRS duration and aging in affected members. The variance was significantly different before and after the age of 40 (ratio variance test; p < 0.001). This was indicative of a threshold effect of age. Two linear regression analyses were thus performed before and after the age of 40.





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