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Figure 3 Nicotine or basic fibroblast growth factor (bFGF) treatment enhance revascularization. (A) Angiographic score at day 0 (immediately postoperation; open bars) and day 21 after treatment (closed bars). (B) Capillary density (capillaries/myocyte) at day 21. (C) Number of collateral vessels per cross-section as determined by light microscopy. (D) Microsphere distribution in the gastrocnemius muscles. (E) Relative Doppler-derived flow in the internal iliac artery of the ischemic limb at rest (open bars) and hyperemia after adenosine infusion (closed bars) at day 21. Relative to the contralateral, nonischemic limb, maximum flow in the internal iliac artery of the ischemic limb increased in the nicotine group by 4.1-fold, in the bFGF group by 3.3-fold, and in the control by 2.0-fold. *p < 0.01 with one-way analysis of variance.
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