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Figure 8 (A) Examples of transferase uridine nucleotide end-labeling method (TUNEL) staining of the peri-infarct zone in myocardial sections from placebo and 17-beta-estradiol (E2)–treated mice 24 h following coronary ligation. TUNEL-positive nuclei are green. Arrows indicate examples of TUNEL-positive cardiomyocyte nuclei. (B) Quantification of TUNEL-positive nuclei expressed as percent total nuclei on a given section. Infarct zone is shown on the left and peri-infarct zone on the right. (C) Caspase 3 activity measured within the infarct zone 24 h following coronary ligation. *p = 0.065, E2 vs. placebo.  p < 0.05, E2 vs. placebo.
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