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Figure 7 Chart of the hypothesis that nitrate tolerance is a dynamic event where increasing severity is mediated by strikingly different molecular mechanisms. Severe nitrate tolerance increases vascular oxidative stress and endothelial dysfunction, whereas moderate forms of nitrate tolerance seem to be restricted to a specific impairment of bioactivation of nitrates to nitric oxide (NO). GTN = glyceryl trinitrate; ISMN = isosorbide mononitrate; NADPH = reduced nicotinamide adenine dinucleotide phosphate.
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