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Figure 6 Influence of increasing doses of isosorbide mononitrate (ISMN) on maximal aortic pressure (AoPmax), minimal aortic pressure (AoPmin), and mean aortic pressure (AoPmean) and heart rate in the anesthetized rabbit in vivo. Intravenous injection of a low dose of 1 mg/kg body weight per day of ISMN induced a significant reduction of AoPmean of 17 ± 3.9% (*p < 0.02 by the t test), whereas the heart rate was not changed. A significant increase in heart rate was observed at 10 mg/kg body weight per day of ISMN (#p < 0.05 by the t test), a dosage with a strong blood pressure-reducing effect (baseline values: AoPmax: 115 ± 9 mm Hg; AoPmean: 99 ± 5 mm Hg; AoPmin: 86 ± 9 mm Hg; heart rate: 201 ± 30 beats/min).
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