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Figure 1 Plasma levels of isosorbide mononitrate (ISMN) in rabbits receiving ISMN at 2 mg/kg body weight per day (ISMN-2) or 200 mg/kg body weight per day (ISMN-200). Blood samples were drawn before (Cmin) and 3 h after oral application of ISMN (Cmax) during the treatment period. In the ISMN-2 group, there was no significant difference between Cmin and Cmax, whereas the Cmax level in ISMN-200 is about 100-fold higher than Cmin (*p = 0.032 vs. ISMN-2; #p < 0.001 vs. Cmin by the unpaired, two-tailed Student t test).
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