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Figure 2 Suppression of ischemia-induced arrhythmias with intrapericardial nitroglycerin. (Top) Coronary artery occlusion consistently provoked severe arrhythmias after intrapericardial saline rather than nitroglycerin administration (n = 5). (Bottom) Arrhythmia severity was reduced 45 min after intrapericardial nitroglycerin (4,000 µg bolus) compared with control (p < 0.05). This reduction in arrhythmia grade appeared as early as 15 min and lasted up to 75 min in four of six animals. Each line type represents an individual experiment. VF = ventricular fibrillation; VPB = ventricular premature beats; VT = ventricular tachycardia (<10-s duration).
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