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Figure 1 Representative coronary arteriograms and electrocardiographic (ECG) tracings (lead V4) of a patient from the fasudil group. (Top left) Baseline coronary arteriogram shows a normal left coronary artery. (Top right) Acetylcholine (ACh) induced angina and downsloping ST-segment depression, but no epicardial spasm. Lactate production was also noted. (Bottom left) The second ACh test after pretreatment with fasudil (F) did not provoke angina, ischemic ECG changes, epicardial spasm, or lactate production. (Bottom right) Normal coronary arteriograms after administration of isosorbide dinitrate.
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