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Figure 3 Relationship between infarct size and organized infarct volume expressed as a percentage of the entire infarct (%OZ/IS) five days after infarction. Control = untreated controls; Glibenclamide = normal rabbits treated with glibenclamide; Hyperchol = hypercholesterolemic rabbits; Hyperchol/nicorandil = hypercholesterolemic rabbits treated with nicorandil. The %OZ/IS was inversely correlated with infarct size in all study groups. However, the slope of the regression line in the hypercholesterolemic group (open circles; y = –27.8x + 100.8, r = 0.96) was significantly more negative than that in the untreated control group (open squares; y = –9.5x + 96.3, r = 0.73). The slope of the regression line in the glibenclamide-treated group (open triangles; y = –18.3x + 101.2, r = 0.96) was also more negative than that in the untreated controls, but the difference did not reach statistical significance. The regression line in the nicorandil-treated hypercholesterolemic group (closed circles; y = –26.7x + 109.4, r = 0.64) was significantly shifted upward compared with that in the hypercholesterolemic group.
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