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Figure 4 Myocardial necrosis in wild-type mice following injection of either saline vehicle or 0.5 mg/kg rosuvastatin before myocardial ischemia and reperfusion. (A) The areas-at-risk per left ventricle were similar among all groups of mice. (B) Pretreatment with rosuvastatin immediately before ischemia (0 h) or 3 h prior to ischemia did not significantly (p = NS) affect the extent of myocardial necrosis. However, pretreatment as short as 6 h significantly (*p < 0.05) attenuated the extent of myocardial necrosis following ischemia and reperfusion.
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