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Figure 2 (A) Effect of nitric oxide inhibition on the myocardial blood flow (MBF) response to adenosine. This figure depicts the MBF at rest and during low and high dose adenosine infusions, after placebo and during infusion of the nitric oxide synthase inhibitor, NG-monomethyl-l-arginine (l-NMMA). The adenosine dose response curve is significantly impaired during l-NMMA vs. placebo (p < 0.05, analysis of variance [ANOVA]). While nitric oxide inhibition significantly reduced MBF to low-dose adenosine, the MBF response to high dose adenosine was unaffected. (B) Effect of nitric oxide inhibition on the myocardial conductance response to adenosine. This figure depicts the myocardial conductance (G) at rest and during low and high dose adenosine infusions, after placebo and during infusion of the nitric oxide synthase inhibitor, l-NMMA. The adenosine dose response curve is significantly impaired during l-NMMA versus placebo (p < 0.05, ANOVA). Nitric oxide inhibition significantly reduced conductance to both low- and high-dose adenosine.
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