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Figure 5 Evidence for poly(adenosine diphosphate-ribose) polymerase (PARP) activation in hearts from rats with chronic heart failure (HF). Immunohistochemical staining for poly(ADP-ribose) formation, an indicator of PARP activation, in sham (a), CHF (b), and PJ34-treated CHF (c) rat hearts. Panel b shows poly(ADP-ribose) formation localized in the nuclei of myocytes and endothelial cells in rats with CHF. Treatment with PJ34 for 10 weeks (c) markedly reduced PARP activation in rats hearts with CHF. Similar immunohistochemical profiles were seen in six to eight hearts per group.
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