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Figure 2 Improvement of cardiac dysfunction by pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase 10 weeks after permanent ligation of left anterior descending coronary artery in a rat model of chronic heart failure (CHF). Effect of CHF and PJ34 on left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular +dP/dt, left ventricular –dP/dt in rats. Results are mean ± 95% confidence interval of 8 to 10 experiments in each group. *p < 0.05 vs. S; #p < 0.05 vs. CHF. BP = blood pressure; CHF + PJ34 = chronic heart failure treated with PJ34 (for 10 weeks); S = sham; S + PJ34 = sham treated with PJ34 (for 10 weeks).
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