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Figure 4 Aggregation of cardiovascular risk factors at the time of the event in six sibships with at least three siblings affected with premature coronary artery disease (P-CAD). Males are represented by squares and females by circles. The numbers beneath the symbols refer to the age when the diagnosis of P-CAD was made, whereas the age for the parents refers to the age at death (numbers in parentheses) or at the time that their P-CAD–affected siblings were recruited (age at death of the father for family no. 39 was unknown). Solid upper left corner = hypertension; solid lower left corner = smoking; solid upper right corner = hypercholesterolemia; and solid lower right corner = obesity and/or diabetes, as defined in the legend to Figure 2. Arrows indicate probands. Plasma cholesterol levels were missing for siblings 1 and 3 from family no. 53, sibling 1 from family no. 80 and sibling 1 from family no. 96, and the diagnosis of hypercholesterolemia was based on values obtained when these individuals were recruited. The father in family no. 80 died of P-CAD at age 49 years.
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