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Figure 5 Transmural unipolar recordings of the left ventricle in the long QT syndrome type 3 (LQT3) model, as presented in Figure 3. (A) Pacing at 600-ms basic cycle length (BCL). The activation-recovery interval (ARI) at the mid-myocardial (Mid) site was longer than that at the epicardial (Epi) and endocardial (Endo) sites, and marked ARI dispersion of 69 ms was observed across the ventricular wall. Faster pacing at 400-ms BCL (B) shortened ARI at all sites, and transmural ARI dispersion was decreased to 30 to 33 ms. Intravenous administration of nicorandil slightly shortened all ARIs at 600-ms BCL pacing (C), and prominent transmural ARI dispersion of 54 to 56 ms persisted across the ventricular wall.
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