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Figure 1 Illustration of the relation between achieved dose of metoprolol controlled-release/extended-release (CR/XL) and heart rate during the titration phase and up to the three-month (mo) visit in the low-dose (open circles) and high-dose metoprolol CR/XL subgroups (solid circles). Mean dose of metoprolol CR/XL and mean heart rate in the low-dose subgroup was the same at the eight-week (w) visit and the three-month visit. At the three-month visit, the reduction in heart rate per milligram metoprolol CR/XL was significantly higher in the low-dose metoprolol CR/XL subgroup (0.21 beats/min [bpm]/mg) compared with the high-dose metoprolol CR/XL subgroup (0.08 beats/min/mg, p < 0.0001).
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