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Figure 1 Quantitative reverse transcription-polymerase chain reaction of bradykinin type-2 receptors (BK-2Rs) in human hearts. (A) Messenger ribonucleic acid (mRNA) expression of BK-2Rs in normal and failing human hearts. (B) The mRNA levels of BK-2Rs are shown as the log ratios between the target and its competitor in the three patient groups. The solid triangle indicates a patient with coronary heart disease (CHD) who did not receive an angiotensin-converting enzyme inhibitor. (C) Expression levels of angiotensin II type I and II receptors (AT-1R and AT-2R, respectively) were analyzed in normal and failing hearts. (D) Levels of BK-2Rs were determined in bradykinin (BK)- and/or captopril (Capto)-treated cultured human coronary artery endothelial cells (HCAEC). *p = 0.01. **p = 0.003. IDC = idiopathic dilated cardiomyopathy; M = marker.
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