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Figure 4 Immunohistochemistry for tenascin (A), alpha-smooth muscle actin ( -SMAc) (B) and vinculin (C) in the dysfunctional human myocardium from a segment with recovery of function after revascularization. Marked deposition of tenascin is noted in the cardiac interstitial space, suggesting an active continuous remodeling process. Interstitial myofibroblasts demonstrate expression of the focal adhesion protein vinculin (C), a factor promoting their attachment to the matrix. Note that vinculin immunoreactivity is also noted in the sarcolemma and the intercalated discs (200x). Counterstained with eosin.
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